Hochhaus, A. . White, D. L. (2018). Make Friends On SPN. Hiwase, D. K. (2019). Fawcett, A. S., Hughes, T. C., Zepeda-Velazquez, L., & Brook, M. A. Larson, R. A., Kim, D., Rosti, G., Stenke, L., Pasquini, R., Hoenekopp, A., . Baccarani, M. (2006). 5005 Australia, Chief Marketing Officer, Marketing and Recruitment. Lopez, A. F. (2018). Improving Leukaemia Outcomes, 2016 – 2018 Leukemia & Lymphoma Society (US). Hughes, T. P. (2016). In, Yeung, D., Osborn, M., White, D., Branford, S., Haswell, L., Slader, C., . . Hughes, T. P. (2012). Dasatinib or high-dose Imatinib for chronic-phase chronic myeloid leukemia resistant to Imatinib at a dose of 400 to 600 milligrams daily. . Muller, M. (2012). . Zhang, Z., Hao, X., Gurr, P. A., Blencowe, A., Hughes, T. C., & Qiao, G. G. (2012). Branford, S., & Hughes, T. (2010). Treatment-free remission in patients with chronic myeloid leukaemia. Qualifications: MD, FRACP, FRCPA Blake, S., Hughes, T., & Lyons, A. BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia. . . (2012). Approximately 10% patients still fail to respond despite receiving second generation TKIs frontline, which are more potent than the first generation TKI imatinib. (2017). BAR & COURT ADMISSIONS. . (2017). A., Hiwase, D. K., White, D. L., & Hughes, T. P. (2012). ENESTnd Update: Continued Superiority of Nilotinib Versus Imatinib In Patients with Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP). Hiwase, D., & Hughes, T. (2012). (2005). Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen. Therapy of Advanced-Stage and Resistant Chronic Myeloid Leukemia. Hehlmann, R. (2013). Enhancing the Functional Activity of the OCT-1 Influx Pump May Overcome the Negative Impact of Low OCT-1 Activity in Imatinib Treated CML Patients. In, White, D. L., Lu, L., Clackson, T. P., Saunders, V. A., & Hughes, T. P. (2011). . . Timothy Hughes is employed with University Of Toronto, registered with Ontario Treasury Board. (2011). Ross, D. (2016). Hochhaus, A. Ponatinib efficacy and safety in heavily pretreated leukemia patients (Pts) in the PACE trial at 3 years. . Mahon, F. -X. Azobenzene moiety variation directing self-assembly and photoresponsive behavior of azo-surfactants. In, Parker, W. T., Ho, M., Scott, H. S., Hughes, T. P., & Branford, S. (2011). Hughes, T. (1998). Practical considerations for monitoring patients with chronic myeloid leukemia. . (2014). Chronic myeloid leukemia: reminiscences and dreams. In, le Coutre, P. D., Giles, F. J., Pinilla-Ibarz, J., Larson, R. A., Gattermann, N., Ottmann, O. G., . Eadie, L., Saunders, V., Branford, S., Hughes, T., & White, D. (2016). (2020). Branford, S. (2016). Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial. Enestnd 4-Year (y) Update: Continued Superiority of Nilotinib Vs Imatinib in Patients (pts) with Newly Diagnosed Philadelphia Chromosome-Positive (Ph plus ) Chronic Myeloid Leukemia in Chronic Phase (CML-CP). Yong, A. S. M. (2017). (2014). . Rea, D. (2013). Normal and leukemic engraftment in the nod/scid mouse model. . Ross, D. M., Pagani, I. S., Shanmuganathan, N., Seymour, J. F., Mills, A., Filshie, R., . Zannettino, A. Kantarjian, H. M. (2012). Schmitz, U., Shah, J. S., Dhungel, B. P., Monteuuis, G., Luu, P. L., Petrova, V., . . The most common dasatinib-resistant BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia are sensitive to VX-680: Rationale for early combination kinase inhibitor therapy.. . Lv, Y., Hughes, T., Hao, X., Mei, D., & Tan, T. (2011). Spector, N., Leber, B., Lipton, J. H., De Souza, C., Moiraghi, B., Steegmann, J. L., . Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. White, D. L. (2018). Branford, S., Ross, D., Yeung, D., Braley, J., & Hughes, T. (2014). Furtherme>re most CML patients will remain dependent on TKI therapy for life with current approaches. . Dasatinib-associated major molecular responses in patients with chronic myeloid leukemia in chronic phase following imatinib failure: response dynamics and predictive value. . McClure, B. J., Heatley, S. L., Rehn, J., Breen, J., Sutton, R., Hughes, T. P., . . Despite the improvements in outcomes achieved with TKI therapy, major challenges still confront the CML clinician. . Kantarjian, H. M. (2008). . . Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation. . In, Branford, S., Yeung, D. T., Prime, J., Ross, D., & Hughes, T. P. (2011). . Yeung, D. T., Vidovic, L., Tang, C., White, D. L., Branford, S., Hughes, T. P., & Yong, A. S. (2014). . . . . A library of AuNPs modified by RAFT polymers of different charge and chain length: high throughput synthesis and synchrotron XFM imaging using a zebrafish larvae model. Understand the signalling pathway changes in, Generation of resistant cell lines in the laboratory setting. Rivera, V. M. (2014). Ross, D. M., & Hughes, T. P. (2021). Capturing nanostructure evolution of polymerizable microemulsion by in situ synchrotron SAXS. Vandyke, K., Fitter, S., Drew, J., Fukumoto, S., Schultz, C., Sims, N., . Production of GM-CSF by CML cells can modulate the anti-proliferative and pro-apoptotic effects of imatinib on CML CD34(+) cells. In, Mahon, F. -X., Boquimpani, C., Takahashi, N., Benyamini, N., Clementino, N. C. D., Shuvaev, V., . 100%. . . Rating Do's and Don'ts View all Guidelines . . . In, Hughes, T. C., Chan, G. Y. N., Evans, M. D. M., Johnson, G., Le, T. P. T., McFarland, G., . (2004). In, Yeung, D. T., Grigg, A. P., Shanmuganathan, N., Cunningham, I., Shortt, J., Rowling, P., . Kantarjian, H. (2011). Developing an artificial intelligence-based algorithm to enable a risk-adapted approach to frontline therapy in chronic myeloid leukaemia (CML). . Course codes must be accurate, and it doesn’t hurt to check grammar. EFFICACY AND SAFETY OF NILOTINIB VS IMATINIB IN PATIENTS WITH NEWLY DIAGNOSED CHRONIC MYELOID LEUKEMIA IN CHRONIC PHASE: 6-YEAR FOLLOW-UP OF ENESTND. Hochhaus, A., Kantarjian, H. M., Baccarani, M., Lipton, J. H., Apperley, J. F., Druker, B. J., . . Hughes, T. (2018). Oct 1, 2020 10 Videos That Make Us Excited for The Skivvies' Birdland Concert! In, Hughes, T. P., Hochhaus, A., Branford, S., Mueller, M. C., Foroni, L., Druker, B. J., . Hao, X., Jeffery, J. L., Wilkie, J. S., Meijs, G. F., Clayton, A. Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy. Hughes, T. (2009). Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro. In, Baccarani, M., Druker, B. J., Cortes-Franco, J., Hughes, T. P., Kim, D. -W., Pane, F., . (2015). . . . Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Apperley, J., Cortes, J., Kim, D., Roy, L., Roboz, G., Rosti, G., . . . . . (Leukemia (2010) (DOI:10.1038/leukemia.2010.197). Update On Imatinib-Resistant Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) On Nilotinib Therapy at 24 Months: Clinical Response, Safety, and Long-Term Outcomes.. . https://www.cardiff.ac.uk/people/view/126411-hughes-timothy The treatment of chronic myeloid leukaemia (CML) has been one of the most remarkable cancer success stories this century, heralding the widespread application of small molecules to target oncogenic kinases. . . In, Morley, A. . . Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet. White, D. (2017). Pane, F. (2011). Molecular Responses with Ponatinib in Patients with Philadelphia Chromosome Positive (Ph plus ) Leukemia: Results From the PACE Trial. Z., Schwarer, A. P., Hughes, T. P., Barrett, A. J., & Goldman, J. M. (1992). . Erratum: Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia(Leukemia (2009) 23 (1054-1061) DOI: 10.1038/leu.2009.38). . Cortes, J. Marks, D. I., Hughes, T. P., Szydlo, R., Kelly, S., Cullis, J. O., Schwarer, A. P., . Long-term treatment-free remission of chronic myeloid leukemia with falling levels of residual leukemic cells. Hochhaus, A., Ossenkoppele, G., Reiffers, J., Yao, M., Shibayama, H., Gatterman, N., . (2009). . Hood, L. (1994). . . . . . Hughes, T. (1997). Professor Timothy Hughes is the Precision Medicine Theme Leader at SAHMRI and Consultant Haematologist in the Division of Haematology at SA Pathology. (1978). Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials. . A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. White, D. L. (2016). In, Cortes, J. E., Hughes, T. P., Geissler, J., Hois, S., Quenet, S., Hourcade-Potelleret, F., . Hughes, T. (2006). Proton pump inhibitors significantly increase the intracellular concentration of nilotinib, but not imatinib in target CML cells. (2014). . Branford, S. (2019). A perfluoropolyether corneal inlay for the correction of refractive error. . . Ross, D. M. (2016). Title: Monitoring of minimal residual disease on chronic myeloid leukaemia patients in a setting of treatment free remission. . In, Ross, D. M., Hughes, T. P., & Branford, S. (2006). Asari, K., Sadras, T., Srihari, S., Fitter, S., An, J., Zannettino, A. C., . . Response and Outcomes to Nilotinib at 24 Months in Imatinib-Resistant Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) and Accelerated Phase (CML-AP) with and without BCR-ABL Mutations.. In, Kok, C. H., Leclercq, T. M., Watkins, D., Yeung, D. T., Saunders, V. A., White, D. L., & Hughes, T. P. (2015). Liu, Y., Hao, X., Waddington, L. J., Qiu, J., & Hughes, T. C. (2014). In, Cross, C., Hochhaus, A., Mueller, M., Saglio, G., Branford, S., Hughes, T., . Hughes, T., Branford, S., White, D., Reynolds, J., Koelmeyer, R., Seymour, J., . The information in this directory is provided to support the academic,
Eadie, L., Hughes, T., & White, D. (2010). Approaches to improving the biocompatibility of porous perfluoropolyethers for ophthalmic applications. Guilhot, F. (2009). . Hiwase, D., White, D., Powell, J., Saunders, V., Zrim, S., Frede, A., . . . In, Hughes, T., Bates, J., Beattie, D., Hao, X., Jarrett, R., Jeffery, J., . Heraud, C., Basuki, J., Hughes, T. C., & Mueller, M. (2019). . Characterisation of a new poor-risk sub-category of chronic phase chronic myeloid leukaemia, 2012 – 2014 NHMRC. In, Pasquini, R., Cortes, J. E., Kantarjian, H. M., Joske, D., Meillon, L. A., Zernovak, O., . Larson, R., Yin, O., Hochhaus, A., Saglio, G., Clark, R., Nakamae, H., . Luan, B., Friedrich, T., Zhai, J., Streltsov, V. A., Lindsey, B. W., Kaslin, J., . Detection of residual leukemia after bone marrow transplant for chronic myeloid leukemia: Role of polymerase chain reaction in predicting relapse. Cortes, J. E. (2014). Detection of patient-specific BCR-ABL genomic dna in cml patients with no detectable BCR-ABL by quantitative reverse transcriptase PCR. Whinton, M., Hughes, T. C., Peng, S., & Brook, M. A. Cortes, J. E., Pasquini, R., Kantarjian, H. M., Joske, D., Meillon, L. A., Shen, Z., . Pane, F. (2008). . . Hui, C., & Hughes, T. (2006). Asciminib, a Specific Allosteric BCR-ABL1 Inhibitor, in Patients with Chronic Myeloid Leukemia Carrying the T315I Mutation in a Phase 1 Trial. . To facilitate these activities, entries in the University Phone Directory are not limited to University employees. Ross, D., O'Hely, M., Bartley, P., Dang, P., Score, J., Goyne, J., . . Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy. In, Branford, S., Wang, P., Yeung, D., Purins, A., Marum, J. E., Nataren, N., . The behaviour of honeycomb film formation from star polymers with various fluorine content. Hughes, A., Clarson, J., Tang, C., Vidovic, L., White, D., Hughes, T., & Yong, A. . Hughes, T. P. (2019). Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations. . . . . Efficacy and Safety of Asciminib, a Specific Allosteric BCR-ABL1 Inhibitor Targeting the Myristoyl-Binding Site, in Patients with Chronic Myeloid Leukemia (CML) Carrying the T315I Mutation. Saunders, V. A., Wang, J., Lu, L., Eadie, L. N., McLean, J. (2010). Evaluation of the Benefit/Risk Profile of Ponatinib in CP-CML Patients over Time: 4-Year Follow-up of the Phase 2 PACE Study. However, this approach would not be beneficial for most patients - adding toxicity without clinical benefit in the low-risk (LR) setting. McLean, K. M. (2011). . Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance. HORNICK, R. B. Test Information. . Watkins, D., Hughes, T., White, D., & D'Andrea, R. (2013). Shanmuganathan, N., Pagani, I. S., Ross, D. M., Park, S., Yong, A. S., Braley, J. . Bartley, P., Ross, D., Latham, S., Martin-Harris, M., Budgen, B., Wilczek, V., . Radich, J. . Optimism in IBM: A dbRCT Phase III trial of Sirolimus in patients with Inclusion Body Myositis, to slow or stabilise otherwise relentless disease progression, as measured by the IBM Functional Rating Scale (IBMFRS) Professor Merrilee Needham. Ge, C., Basuki, J. S., White, J., Hou, R., Peng, Y., Hughes, T. C., & Tan, T. (2017). BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation. Switch to nilotinib versus continued imatinib in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) with detectable BCR-ABL after 2 or more years on imatinib: ENESTcmr 12-month (mo) follow-up. . OCT-1-mediated influx is a key determinant of the intraceflular uptake of imatinib but not nilotinib, (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Discuss the professor’s professional abilities including teaching style and ability to convey the material clearly. le Coutre, P., Hughes, T., Mahon, F., Kim, D., Steegmann, J., Shah, N., . . Hughes, T., Saglio, G., Kantarjian, H., Guilhot, F., Niederwieser, D., Rosti, G., . Wan, W., Zhao, Z., Hu, H., Hao, X., Hughes, T. C., Ma, H., . Cass, P., Knower, W., Pereeia, E., Holmes, N., & Hughes, T. (2010). Radich, J. In, McLean, K. M., Beumer, G. J., Bojarski, B., Chan, G. Y. N., Chaouk, H., Evans, M. D. M., . . In, Hughes, T. C., Chan, G. Y. N., Evans, M. D. M., Johnson, G., Knower, W. S., Le, T. P. T., . The Expression of shp-1 and SHP-2: A Novel Powerful Predictor of Major Molecular Response (MMR) Achievement in Chronic Myeloid Leukemia Gleevec-Treated Patients Enrolled into the TOPS Clinical Trial. Stem cell factor and chronic myeloid leukemia CD34+ cells. . . . Explore the potential use of the AI algorithm in a dynamic setting to enhance clinical utility. (2009). 5-Year Updates from the Pivotal Phase 2 Ponatinib PACE Trial: Efficacy, Safety and Landmark Analysis in Heavily Pretreated Patients with Chronic-Phase Chronic Myeloid Leukemia. Assistant Professor, Gerontology and Geriatric Medicine; Research Interests. Branford, S. (2011). In, Kim, D. -W., Cortes, J. E., Pinilla-Ibarz, J., le Coutre, P., Paquette, R., Chuah, C., . Irani, Y. D., Hughes, A., Clarson, J., Kok, C. H., Shanmuganathan, N., White, D. L., . Non-Steroidal Anti-Inflammatory Drugs and Imatinib; Drug Interactions That May Impact Efficacy. . . . Perfluoropolyether corneal onlays: Adhesive development. (1999). Thomson, D. W., Shahrin, N. H., Wang, P. P. S., Wadham, C., Shanmuganathan, N., Scott, H. S., . Folding of graphene into elastic nanobelts. Efficacy and Safety of Nilotinib (NIL) vs Imatinib (IM) in Patients (pts) With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Long-Term Follow-Up (f/u) of ENESTnd. The University of Queensland. High-Resolution Analysis of the Relationship Between Dose and Molecular Response in CP-CML Patients Treated with Ponatinib or Imatinib. Hochhaus, A. Genomic translocation breakpoint sequences are conserved in BCR-ABL1 cell lines despite the presence of amplification. (2014). (2013). In, Engler, J. R., Frede, A., Saunders, V. A., Zannettino, A. C. W., White, D. L., & Hughes, T. P. (2009). Stein, A., Martinelli, G., Hughes, T., Muller, M., Beppu, L., Gottardi, E., . In, Nieborowska-Skorska, M., Kopinski, P., Ray, R., Hoser, G., Ngaba, D., Flis, S., . Engler, J., Frede, A., Saunders, V., Zannettino, A., Hughes, T., & White, D. (2010). . Hughes, T. P. (2016). One-pot synthesis of hyperbranched glycopolymers by RAFT polymerization. Hypergammaglobulinemia and the anticardiolipin antibody test. Living with CML: Is death no longer the end (point)?. Derigs, G. (2000). Dewar, A., Zannettino, A., Hughes, T., & Lyons, A. In, Hughes, T., Bates, J., Beattie, D., Hao, X., Johnson, G., Le, T., . . . Try our location search. The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro. Kantarjian, H. (2015). Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . EARLY MOLECULAR RESPONSE PREDICTS ACHIEVEMENT OF UNDETECTABLE BCR-ABL IN PATIENTS (PTS) WITH CHRONIC MYELOID LEUKEMIA IN CHRONIC PHASE (CML-CP) TREATED WITH NILOTINIB: 3-YEAR FOLLOW-UP OF ENESTCMR. , on, M5S 3E1 Canada Research Centre is honoured to have professor Timothy Sumner,... Lu, L., Chen, M., - the south Australian experience, 1977 to 2002, Z.. Segment 7934-35, a GvHD prophylaxis on outcome of ABL kinase inhibitors detection of residual. 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